Angiogenesis is impaired by hypercholesterolemia: Role of asymmetric dimethylarginine Academic Article uri icon

Overview

MeSH Major

  • Angiogenesis Inhibitors
  • Apolipoproteins E
  • Arginine
  • Enzyme Inhibitors
  • Hypercholesterolemia
  • Neovascularization, Physiologic
  • Nitric Oxide Synthase

abstract

  • The derangement of the NO synthase pathway that occurs in hypercholesterolemia is associated with an impairment of angiogenesis. The lipid-induced impairment of angiogenesis can be reversed by oral administration of L-arginine and can be mimicked in normocholesterolemic animals by administration of an NO synthase antagonist. The data are consistent with the hypothesis that ADMA is an endogenous inhibitor of angiogenesis.

publication date

  • September 19, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10993861

Additional Document Info

start page

  • 1414

end page

  • 9

volume

  • 102

number

  • 12