Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine- associated thrombotic thrombocytopenic purpura Academic Article uri icon

Overview

MeSH Major

  • Immunoglobulin G
  • Metalloendopeptidases
  • Platelet Aggregation Inhibitors
  • Purpura, Thrombotic Thrombocytopenic
  • Ticlopidine
  • von Willebrand Factor

abstract

  • In the patients who developed ticlopidine-associated TTP, autoantibodies to the vWF metalloproteinase were formed; this led to the same type of vWF abnormalities observed in patients with idiopathic acute TTP. The findings suggest that failure to process large and unusually large vWF multimers in vivo caused binding of vWF to platelets, systemic platelet thrombosis, and TTP.

publication date

  • May 16, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3152977

PubMed ID

  • 10819702

Additional Document Info

start page

  • 794

end page

  • 9

volume

  • 132

number

  • 10