Granulocyte-colony stimulating factor and multiple cycles of strongly myelosuppressive alkylator-based combination chemotherapy in children with neuroblastoma Academic Article Article uri icon

Overview

MeSH Major

  • Antibodies, Bispecific
  • Antigens, Neoplasm
  • Antineoplastic Agents
  • Carcinoma, Hepatocellular
  • Immunotherapy
  • Liver Neoplasms
  • Receptors, Antigen
  • Recombinant Fusion Proteins

abstract

  • With multiple cycles of strongly myelosuppressive alkylator-based combination chemotherapy, prophylactic use of G-CSF hastened ANC recovery but did not reduce the incidence of febrile episodes, had little impact on infection rates, did not yield augmented dose intensity, was associated with prolonged thrombocytopenia, and had no effect on response rates of neuroblastoma. The data support more limited use of G-CSF.

publication date

  • November 15, 2000

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(20001115)89:10<2122::AID-CNCR13>3.0.CO;2-K

PubMed ID

  • 11066054

Additional Document Info

start page

  • 2122

end page

  • 30

volume

  • 89

number

  • 10