Novel strategies and therapeutics for the treatment of prostate carcinoma Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Molecular Diagnostic Techniques
  • Molecular Targeted Therapy
  • Neoplasms

abstract

  • Development of novel agents requires consideration of where in the natural history of the disease they should be applied. In addition, understanding the genetic and molecular alterations that occur as the disease progresses from a localized to a metastatic state, and from androgen dependence to independence, is necessary. Clinical trial design will require consideration of cytostatic and cytotoxic effects, the status of pathways not directly targeted, and potentially unexpected influences on prostate specific antigen expression by these agents.

publication date

  • September 15, 2000

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(20000915)89:6<1329::AID-CNCR19>3.0.CO;2-Q

PubMed ID

  • 11002230

Additional Document Info

start page

  • 1329

end page

  • 48

volume

  • 89

number

  • 6