Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Cerebrovascular Circulation
  • Peptide Fragments
  • Somatosensory Cortex

abstract

  • Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide (Abeta), play a critical role in the pathogenesis of Alzheimer's dementia. We report that transgenic mice overexpressing APP and Abeta have a profound attenuation in the increase in neocortical blood flow elicited by somatosensory activation. The impairment is highly correlated with brain Abeta concentration and is reproduced in normal mice by topical neocortical application of exogenous Abeta1-40 but not Abeta1-42. Overexpression of M146L mutant presenilin-1 in APP mice enhances the production of Abeta1-42 severalfold, but it does not produce a commensurate attenuation of the hyperemic response. APP and Abeta overexpression do not diminish the intensity of neural activation, as reflected by the increase in somatosensory cortex glucose usage. Thus, Abeta-induced alterations in functional hyperemia produce a potentially deleterious mismatch between substrate delivery and energy demands imposed by neural activity.

publication date

  • August 15, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC16934

PubMed ID

  • 10944232

Additional Document Info

start page

  • 9735

end page

  • 40

volume

  • 97

number

  • 17