Identification and characterization of circulating prostate carcinoma cells Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Molecular Diagnostic Techniques
  • Molecular Targeted Therapy
  • Neoplasms

abstract

  • Although the significance of the cluster remains undetermined, observation suggests that the cluster has the ability to circulate as a microtumor and subsequently arrest in the small veins and capillaries. It is hypothesized that the clusters could escape certain facets of immune surveillance and possibly gain a selective growth advantage over single cells in a distant site. Further hypothesis proposes that arrested cells recruit growth-promoting nutrients, which would result in the invasion of local blood vessels and vascularization.

publication date

  • June 15, 2000

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(20000615)88:12<2787::AID-CNCR18>3.0.CO;2-2

PubMed ID

  • 10870062

Additional Document Info

start page

  • 2787

end page

  • 95

volume

  • 88

number

  • 12