Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach Academic Article uri icon

Overview

MeSH Major

  • Influenza A virus
  • Influenza B virus
  • Influenza Vaccines
  • Viral Nonstructural Proteins

abstract

  • We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.

publication date

  • April 11, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC18238

Digital Object Identifier (DOI)

  • 10.1073/pnas.070525997

PubMed ID

  • 10725408

Additional Document Info

start page

  • 4309

end page

  • 14

volume

  • 97

number

  • 8