Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease Academic Article uri icon

Overview

MeSH Major

  • DNA, Mitochondrial
  • Mutation, Missense
  • Parkinson Disease
  • RNA, Transfer

abstract

  • mtDNA mutations with a high mutational burden (present in a high percentage of mtDNA molecules in an individual) in complex I or tRNA genes do not play a major role in the risk of PD in most PD patients. Further investigations are necessary to determine if any of the rare mtDNA mutations identified in PD patients play a role in the pathogenesis of PD in those few cases.

publication date

  • February 8, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10680807

Additional Document Info

start page

  • 703

end page

  • 9

volume

  • 54

number

  • 3