Transgenic mice overexpressing γ-aminobutyric acid transporter subtype I develop obesity Academic Article uri icon

Overview

MeSH Major

  • Carrier Proteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Obesity
  • Organic Anion Transporters

abstract

  • Transgenic mice ubiquitously overexpressing murine gamma-aminobutyric acid transporter subtype I were created. Unexpectedly, these mice markedly exhibited heritable obesity, which features significantly increased body weight and fat deposition. Behavioral examination revealed that transgenic mice have slightly reduced spontaneous locomotive capacity and altered feeding pattern. This preliminary finding indicates that the inappropriate level of gamma-aminobutyric acid transporters may be directly or indirectly involved in the pathogenic mechanism underlying certain types of obesity.

publication date

  • December 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11191352

Additional Document Info

start page

  • 303

end page

  • 10

volume

  • 10

number

  • 4