Antidepressants in long-term therapy: A review of tricyclic antidepressants and selective serotonin reuptake inhibitors
Antidepressive Agents, Tricyclic
Serotonin Uptake Inhibitors
Overall, studies conclude that depression is a recurrent, often chronic, lifetime illness requiring long-term treatment. Continuation therapy of 3 to 6 months after acute stabilization should be considered standard for all depressed patients, and maintenance therapy should be considered for many depressed patients. Newer agents, such as the SSRIs, are preferable to the TCAs for long-term treatment based on their superior tolerability and safety. However, because of the limited number of maintenance studies, further studies using a prospective, randomized design are needed to address this issue.