In microdissected ductal carcinoma in situ, HER-2/neu amplification, but not p53 mutation, is associated with high nuclear grade and comedo histology Academic Article Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Breast Neoplasms, Male
  • Hemangioma
  • Hemangiosarcoma
  • Ki-67 Antigen

abstract

  • The presence of HER-2/neu amplification, but not p53 mutations, correlates with histologic subtype and nuclear grade. The relatively frequent occurrence of HER-2/neu amplification and p53 mutations in DCIS tissue and their absence in normal breast tissue suggest that these genetic aberrations are important early in breast duct carcinogenesis.

publication date

  • December 2000

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(20001201)89:11<2153::AID-CNCR2>3.0.CO;2-O

PubMed ID

  • 11147584

Additional Document Info

start page

  • 2153

end page

  • 60

volume

  • 89

number

  • 11