Autophagy as a regulated pathway of cellular degradation Article Report uri icon


MeSH Major

  • Proteins


  • Macroautophagy is a dynamic process involving the rearrangement of subcellular membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole where the sequestered cargo is degraded and recycled. This process takes place in all eukaryotic cells. It is highly regulated through the action of various kinases, phosphatases, and guanosine triphosphatases (GTPases). The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway includes a ubiquitin-like protein conjugation system and a protein complex that directs membrane docking and fusion at the lysosome or vacuole. Macroautophagy plays an important role in developmental processes, human disease, and cellular response to nutrient deprivation.

publication date

  • December 2000



  • Report


Digital Object Identifier (DOI)

  • 10.1126/science.290.5497.1717

PubMed ID

  • 11099404

Additional Document Info

start page

  • 1717

end page

  • 21


  • 290


  • 5497