Novel association of haemophagocytic syndrome with Kaposi's sarcoma-associated herpesvirus-related primary effusion lymphoma Academic Article Article uri icon


MeSH Major

  • Contrast Media
  • Drug Hypersensitivity
  • Extravasation of Diagnostic and Therapeutic Materials
  • Gadolinium DTPA
  • Gastrointestinal Tract
  • Iodine Compounds
  • Postoperative Complications


  • Haemophagocytic syndrome (HPS) is a fulminant, often fatal, systemic illness that occurs in association with infection and malignancy. We provide the first report of HPS that heralded a primary effusion lymphoma (PEL), a rare neoplasm linked to Kaposi's sarcoma-associated herpesvirus. The patient was a 38-year-old man with acquired immunodeficiency syndrome who presented with fever, sweats, lymphadenopathy, splenomegaly and refractory anaemia. Examination of the spleen demonstrated haemophagocytosis; analysis of ascites revealed PEL. Treatment with chemotherapy and ganciclovir resulted in complete remission of both conditions. This case illustrates the diagnostic challenges posed by HPS and supports the trial of antiviral agents in combination with chemotherapy in patients with PEL.

publication date

  • December 2000



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.2000.02478.x

PubMed ID

  • 11167749

Additional Document Info

start page

  • 1112

end page

  • 5


  • 111


  • 4