Nucleotide-evoked ion transport and [Ca2+](i) changes in normal and hyperhidrotic human sweat gland cells Academic Article Article uri icon


MeSH Major

  • Eccrine Glands
  • Epithelial Cells
  • Hyperhidrosis
  • Sweat


  • Apical and basolateral application of ATP and UTP evoked [Ca(2+)](i) and short circuit current (Isc) increases in normal and hyperhidrotic human eccrine sweat gland cells grown into functionally polarised epithelia on permeable supports. Basolateral application to hyperhidrotic cells exhibited a markedly greater increase in Isc than in normal cells. Hyperhidrotic cells also demonstrated differences from the normal in [Ca(2+)](i) and Isc responses to ATP when pre-treated with thapsigargin. The data demonstrate the presence of apical and basolateral receptors that allow nucleotides to increase [Ca(2+)](i) and Isc. The results suggest that changes from the normal in transepithelial ion transport contribute to the characteristic excessive fluid production of hyperhidrotic sweat glands.

publication date

  • September 2000



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0014-2999(00)00570-7

PubMed ID

  • 10969142

Additional Document Info

start page

  • 45

end page

  • 8


  • 403


  • 1-2