The importance of genetic polymorphisms in renal transplantation Article uri icon

Overview

MeSH Major

  • HLA Antigens
  • Immunoassay
  • Isoantibodies
  • Kidney Transplantation

abstract

  • Genetic variations including single nucleotide polymorphisms, dinucleotide repeats and microsatellites have been identified in a number of genes encoding cytokines, cytokine receptors, chemokines and their receptors, adhesion molecules. Several of the polymorphisms are located in the promoter region of the gene, affect transcription or translation, and not infrequently determine the level of expression of the protein product. An interesting and testable hypothesis for the clinical heterogeneity and differential responsiveness in allograft recipients is genetic variation. These nucleotide sequence variations, polymorphisms located in genes contributing to immune repertory and in genes responsible for drug metabolism, are excellent candidates for the differential clinical phenotype.

publication date

  • April 12, 2000

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1097/00042307-200003000-00004

PubMed ID

  • 10785845

Additional Document Info

start page

  • 71

end page

  • 5

volume

  • 10

number

  • 2