Idiopathic pulmonary fibrosis: Is lung biopsy essential?
Congresses as Topic
Lung Diseases, Interstitial
National Heart, Lung, and Blood Institute (U.S.)
Idiopathic interstitial pneumonias often mimic idiopathic pulmonary fibrosis. Patterns seen on high-resolution CT scans and surgical lung biopsy specimens differentiate these diseases and help determine the patient's prognosis and response to therapy. Lung biopsy can be used to exclude alternative etiologies, assess the extent of inflammatory and fibrotic lesions, and discern a histopathologic pattern. The degree of fibrosis or inflammation on open lung biopsy has prognostic value, but accuracy may be limited by variation in histopathologic features from lobe to lobe. Compared with open lung biopsy, video-assisted thoracoscopic lung biopsy is associated with less morbidity and reduced length of hospital stay.