Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis Academic Article uri icon

Overview

MeSH Major

  • Antibiotics, Antineoplastic
  • Apoptosis
  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Mitomycin
  • Prostaglandin-Endoperoxide Synthases

abstract

  • MMC upregulates COX-2 expression, which appears to be an antiapoptotic signal downstream of PKC. Selective inhibition of COX-2 can therefore provide a novel way to enhance MMC-induced apoptosis independent of inhibiting PKC.

publication date

  • May 3, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10803922

Additional Document Info

start page

  • 389

end page

  • 96

volume

  • 45

number

  • 5