Striatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson's disease: Implications for a preclinical diagnosis Academic Article uri icon

Overview

MeSH Major

  • Carrier Proteins
  • Dopamine
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Parkinson Disease
  • Radiopharmaceuticals
  • Tropanes

abstract

  • Use of [I-123] IPT and single photon emission computed tomography demonstrates a reduction of dopamine transporter binding in patients with early Parkinson's disease. Significantly reduced IPT binding already observed in the ipsilateral striatum of patients with Hoehn and Yahr stage I demonstrates the potential of this method to detect preclinical disease.

publication date

  • February 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10681078

Additional Document Info

start page

  • 205

end page

  • 8

volume

  • 57

number

  • 2