Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera Academic Article uri icon

Overview

MeSH Major

  • Amyotrophic Lateral Sclerosis
  • Motor Neurons
  • Oculomotor Muscles
  • Presynaptic Terminals

abstract

  • In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

publication date

  • January 11, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10636164

Additional Document Info

start page

  • 252

end page

  • 5

volume

  • 54

number

  • 1