CD4+ T cells kill HLA-class-II-antigen-positive melanoma cells presenting peptide in vitro Academic Article uri icon

Overview

MeSH Major

  • Antigen-Presenting Cells
  • Antigens, Neoplasm
  • CD4-Positive T-Lymphocytes
  • HLA-D Antigens
  • Melanoma

abstract

  • Peptide-specific CD4(+) T cells kill melanoma cells in vitro when they recognize peptide presented by the tumor cell in the context of HLA class II antigen. Direct cell contact is not required, suggesting that it is a cytokine-mediated event. Immunotherapy, using primed CD4(+) T cells and peptide, may be beneficial in patients whose tumors express HLA class II antigens or can be induced to do so with IFNgamma.

publication date

  • February 5, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10663609

Additional Document Info

start page

  • 621

end page

  • 6

volume

  • 48

number

  • 11