A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Growth Inhibitors
  • Methionine
  • Molecular Mimicry
  • Prostatic Neoplasms
  • ras Proteins

abstract

  • L-744,832 could be safely administered over a protracted period of time to mice at doses which were markedly inhibitory to the growth of three human prostate tumor xenografts and in combination with PTXL was also well tolerated and brought about some regression of the TSU-PR1 tumor. Overall, these results suggest that L-744,832 could be clinically useful for long-term treatment of early-stage prostate cancer in patients and as an adjunct to cytotoxic therapy for late stages of this disease.

publication date

  • July 15, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10912583

Additional Document Info

start page

  • 79

end page

  • 83

volume

  • 46

number

  • 1