Autoimmune mechanisms in movement disorders. Academic Article uri icon

Overview

MeSH

  • Antibodies, Monoclonal
  • B-Lymphocytes
  • Biological Markers
  • Brain
  • Humans
  • Neurons
  • Obsessive-Compulsive Disorder
  • Plasmapheresis
  • Tourette Syndrome

MeSH Major

  • Autoantibodies
  • Movement Disorders

abstract

  • A number of disorders, including childhood-onset obsessive compulsive disorder (OCD) and Gilles de la Tourette's syndrome (TS), are known to be neurobiological in nature. Both TS and OCD are neuropsychiatric diagnoses that involve congitive and perceptual dysfunction in addition to motor and psychiatric manifestations. The association of the B-cell marker with both Sydenham's chorea and a group of neuropsychiatric disorders, such as OCD, tics, and TS, has been useful as a marker in these diseases. This evidence, coupled with the recent finding of anti-brain antibodies in the sera of these patients, raises a number of interesting questions concerning the pathological mechanisms involved in these diseases. Thus, further molecular characterization of the brain and streptococcal antigens will be crucial to our understanding of the neurophysiological processes involved in these disorders.

publication date

  • June 2000

has subject area

  • Antibodies, Monoclonal
  • Autoantibodies
  • B-Lymphocytes
  • Biological Markers
  • Brain
  • Humans
  • Movement Disorders
  • Neurons
  • Obsessive-Compulsive Disorder
  • Plasmapheresis
  • Tourette Syndrome

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 10914411

Additional Document Info

start page

  • 103

end page

  • 107

volume

  • 7

number

  • 2