Developmental considerations of neurotoxic exposures Review uri icon

Overview

MeSH Major

  • Developmental Disabilities
  • Neurotoxicity Syndromes
  • Neurotoxins

abstract

  • In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed. In addition, the authors selectively review preclinical data identifying mechanisms contributing to neurobehavioral compromise, and clinical data identifying deficits resulting from exposure to two classes of neurotoxins: exposure to drugs of abuse, including alcohol, nicotine, and cocaine; and exposure to environmental agents, including lead, methyl-mercury, PCBs, and organophosphorus compounds.

publication date

  • August 24, 2000

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 10873230

Additional Document Info

start page

  • 541

end page

  • 62

volume

  • 18

number

  • 3