Treatment for primary CNS lymphoma: The next step
Antineoplastic Combined Chemotherapy Protocols
Central Nervous System Neoplasms
Increasing the dose of MTX and adding procarbazine and vincristine improved disease control and overall survival in patients with newly diagnosed PCNSL. Younger patients in particular fared extremely well with this treatment regimen. In older patients, deferring whole-brain RT did not compromise overall survival but did reduce treatment-related toxicity.