Vacuolar-type H+-ATPase distribution in unstimulated and acetylcholine-activated isolated human eccrine sweat glands Academic Article Article uri icon


MeSH Major

  • Eccrine Glands
  • Epithelial Cells
  • Hyperhidrosis
  • Sweat


  • The presence and cellular distribution of subunits of the V1 sector of the vacuolar-type H+ -ATPase (V-ATPase) was investigated in isolated human eccrine sweat glands. In every instance, V-ATPase was located in the cytoplasm and apical membranes of the luminal cells of the reabsorptive duct segment. In the secretory coil, both diffuse and perinuclear staining was demonstrated in the secretory cells, with additional expression at the apical and basolateral membranes and on the intercellular canaliculi. There was no detectable difference in V-ATPase expression as a result of prior application of 100 microM acetylcholine.

publication date

  • September 12, 2000



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1023/A:1004087120735

PubMed ID

  • 10987504

Additional Document Info

start page

  • 409

end page

  • 13


  • 32


  • 7