Phase II trial of 2-chlorodeoxyadenosine in patients with relapsed/refractory acute myeloid leukemia: A study of the Eastern Cooperative Oncology Group (ECOG), E5995 Academic Article Article uri icon


MeSH Major

  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 9
  • Leukemia, Myeloid
  • Translocation, Genetic


  • 2-Chlorodeoxyadenosine (2-CdA) is a purine analog which has anti-leukemic activity in phase II trials in pediatric acute myeloid leukemia (AML) patients. An adult phase I trial suggested possible similar activity although neurotoxicity at higher doses was seen. We conducted a phase II trial of 2-CdA in patients with relapsed or refractory AML. 2-CdA was administered by continuous intravenous infusion at a dose of 17 mg/m(2) per day x5 days. Patients not achieving aplasia by day 21 were eligible for a second course of therapy. Fifteen patients (nine relapsed and six refractory AML) were enrolled including seven men and eight women with a median age of 60 years and median ECOG PS of 1. There were five deaths on study due to infections (two), AML (two), or hepatic failure (one). The 2-CdA was well tolerated without severe nausea, vomiting or stomatitis (all

publication date

  • January 2000



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0145-2126(00)00043-6

PubMed ID

  • 10996206

Additional Document Info

start page

  • 871

end page

  • 5


  • 24


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