Chemical synthesis and biological properties of pyridine epothilones Academic Article Article uri icon

Overview

MeSH Major

  • Financing, Organized
  • Medical Oncology
  • National Institutes of Health (U.S.)
  • Neoplasms
  • Research Support as Topic
  • Training Support

abstract

  • The biological screening results in this study established the importance of the nitrogen atom at the ortho position as well as the beneficial effect of a methyl substituent at the 4- or 5-position of the pyridine ring. Two pyridine epothilone B analogs (i.e. compounds 3 and 4) possessing higher potencies against drug-resistant tumor cells than epothilone B, the most powerful of the naturally occurring epothilones, were identified.

publication date

  • October 5, 2000

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S1074-5521(00)00006-5

PubMed ID

  • 11048950

Additional Document Info

start page

  • 593

end page

  • 9

volume

  • 7

number

  • 8