Effect of transfusional iron overload on immune response Academic Article uri icon

Overview

MeSH Major

  • Blood Transfusion
  • CD8-Positive T-Lymphocytes
  • Deferoxamine
  • Iron Overload
  • beta-Thalassemia

abstract

  • Increased susceptibility to infectious disease is observed in persons with transfusion-dependent thalassemia and iron overload who experience increased exposure to pathogens and chronic immune stimulation. An abnormal low CD8(+) T (LT8) immune phenotype defines a subgroup of patients. The CD8(+) T cell immunophenotype is stable despite continued blood transfusion and is independent of age. CD8(+) T cells, but not CD4(+) T cells, were modulated during intravenous chelation with deferoxamine. Return to characteristic pretreatment levels of CD8 was observed in both the low and the normal groups, suggesting the possibility of a set point. Proliferative response to mitogens and antigens was increased by chelation. Because CD8(+) T cells are important in immune response to infectious disease, these studies suggest that intrinsic CD8(+) T cell subset differences may be a critical factor in determining susceptibility to infection independent of transfusional iron overload or alloantigen exposure.

publication date

  • September 25, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10944493

Additional Document Info

start page

  • S115

end page

  • 21

volume

  • 182

number

  • 3 SUPPL. 1