Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia Academic Article Article uri icon


MeSH Major

  • Asthma
  • Bronchoalveolar Lavage Fluid
  • Glycoproteins


  • A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of transforming growth factor (TGF)-beta. After splenectomy, the patient achieved clinical remission, the natural killer (NK) cell number increased and the pattern of cytokine production showed normalization of interleukin (IL)-2, IL-4, IL-10, TGF-beta and abolition of interferon (IFN)-gamma production. We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF-beta production.

publication date

  • November 11, 2000



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.2000.02296.x

PubMed ID

  • 11054090

Additional Document Info

start page

  • 968

end page

  • 70


  • 110


  • 4