Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy Review uri icon

Overview

MeSH Major

  • Antigens, Neoplasm
  • Carboxypeptidases
  • Prostatic Neoplasms

abstract

  • Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.

publication date

  • November 13, 2000

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 11062377

Additional Document Info

start page

  • 217

end page

  • 22;discussion 223

volume

  • 4

number

  • 3