An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
Education, Medical, Continuing
We concluded that the endogenous NO synthase inhibitor ADMA is synthesized in human endothelial cells. Asymmetric dimethylarginine increases endothelial oxidative stress and potentiates monocyte binding. Asymmetric dimethylarginine may be an endogenous proatherogenic molecule.