Metabolism of [123I]epidepride may affect brain dopamine D2 receptor imaging with single-photon emission tomography Academic Article uri icon


MeSH Major

  • Benzamides
  • Brain
  • Iodine Radioisotopes
  • Pyrrolidines
  • Receptors, Dopamine D2
  • Tomography, Emission-Computed, Single-Photon


  • Iodine-123 labelled epidepride is a novel radiopharmaceutical for the study of cerebral dopamine D2 receptors using single-photon emission tomography (SPET). A lipophilic labelled metabolite of [123I]epidepride which may enter the brain and hamper the quantitation of receptors has been observed in human plasma. In the present study, gradient high-performance liquid chromatography (HPLC) was used to investigate the plasma concentration of the lipophilic labelled metabolite and its correlation to SPET imaging of striatal dopamine D2 receptors. A linear regression fit showed a negative correlation between the amount of the lipophilic labelled metabolite and the striatum to cerebellum ratio (n=16, R=-0.58, P<0.02), suggesting that plasma metabolite analysis is essential when imaging dopamine D2 receptors with SPET using [123I]epidepride.

publication date

  • January 2000



  • Academic Article



  • eng

PubMed ID

  • 10755727

Additional Document Info

start page

  • 206

end page

  • 8


  • 27


  • 2