Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate Academic Article Article uri icon


MeSH Major

  • Biomarkers, Tumor
  • Leukemia, Lymphoid
  • Lymphoma
  • Pathology, Molecular


  • Vascular endothelial cells undergo morphogenesis into capillary networks in response to angiogenic factors. We show here that sphingosine-1-phosphate (SPP), a platelet-derived bioactive lipid, activates the EDG-1 and -3 subtypes of G protein-coupled receptors on endothelial cells to regulate angiogenesis. SPP induces the Gi/mitogen-activated protein kinase/cell survival pathway and the small GTPase Rho- and Raccoupled adherens junction assembly. Both EDG-1-and EDG-3-regulated signaling pathways are required for endothelial cell morphogenesis into capillary-like networks. Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neovessels in vivo. These data define SPP as a novel regulator of angiogenesis.

publication date

  • October 29, 1999



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0092-8674(00)81661-X

PubMed ID

  • 10555146

Additional Document Info

start page

  • 301

end page

  • 12


  • 99


  • 3