Requirement for Tec kinases Rlk and ltk in T cell receptor signaling and immunity Academic Article Article uri icon

Overview

MeSH Major

  • Science

abstract

  • T cell receptor (TCR) signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other tyrosine kinases are less clear. Combined deletion in mice of two Tec kinases, Rlk and Itk, caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo. Molecular events immediately downstream from the TCR were intact in rlk-/-itk-/- cells, but intermediate events including inositol trisphosphate production, calcium mobilization, and mitogen-activated protein kinase activation were impaired, establishing Tec kinases as critical regulators of TCR signaling required for phospholipase C-gamma activation.

publication date

  • April 23, 1999

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1126/science.284.5414.638

PubMed ID

  • 10213685

Additional Document Info

start page

  • 638

end page

  • 41

volume

  • 284

number

  • 5414