Cellular effects of β-particle delivery on vascular smooth muscle cells and endothelial cells: A dose-response study Academic Article uri icon

Overview

MeSH Major

  • Beta Particles
  • Endothelium, Vascular
  • Muscle, Smooth, Vascular
  • Phosphorus Radioisotopes

abstract

  • 32P-labeled oligonucleotide was highly effective in inhibiting proliferation of both VSMCs and ECs in a dose-dependent fashion, with ECs showing a higher resistance to these effects. beta irradiation-induced G1 arrest was not associated with cytotoxicity and apoptosis, thus demonstrating a potent cytostatic effect of beta-based therapy. This effect, coupled to that on VSMC migration inhibition and the appearance of a contractile phenotype, reinforced the potential of ionizing radiation to prevent neointima formation after angioplasty.

publication date

  • March 23, 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10086973

Additional Document Info

start page

  • 1477

end page

  • 84

volume

  • 99

number

  • 11