Glucose control and long-term survival in biobreeding/worcester rats after intraperitoneal implantation of hydrophilic macrobeads containing porcine islets without immunosuppression Academic Article uri icon

Overview

MeSH Major

  • Blood Glucose
  • Islets of Langerhans Transplantation
  • Peritoneum
  • Transplantation, Heterologous

abstract

  • Our results indicate that macrobeads containing porcine islets implanted intraperitoneally in natural insulin-dependent diabetic BB/Wor rats are capable of normalizing glucose control, permitting a normal life span, and preventing the renal changes normally associated with diabetes. Therefore, further short- and long-term studies of porcine islet macrobead implantation in chemically induced and naturally occurring diabetes in rodents, as well as larger animals including dogs, monkeys and possibly humans, are merited.

publication date

  • December 15, 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10609945

Additional Document Info

start page

  • 1693

end page

  • 700

volume

  • 68

number

  • 11