A fully synthetic globo H carbohydrate vaccine induces a focused humoral response in prostate cancer patients: A proof of principle Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Bone Neoplasms
  • Radium

abstract

  • Human trials on the globo H carbohydrate vaccine (see picture, KLH = the carrier protein keyhole limpet hemocyanin) show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer. Furthermore, these antibodies not only recognize synthetic antigens, but also globo H-positive tumors in biopsy extracts and tumor tissues.

publication date

  • February 15, 1999

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 29711780

Additional Document Info

start page

  • 563

end page

  • 566

volume

  • 38

number

  • 4