New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Article Report uri icon


MeSH Major

  • Apoptosis
  • Carrier Proteins
  • Phosphatidylinositol 3-Kinases
  • Protein-Serine-Threonine Kinases


  • The most recently discovered PTEN tumor suppressor gene has been found to be defective in a large number of human cancers. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors. PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides.

publication date

  • April 13, 1999



  • Report


Digital Object Identifier (DOI)

  • 10.1073/pnas.96.8.4240

PubMed ID

  • 10200246

Additional Document Info

start page

  • 4240

end page

  • 5


  • 96


  • 8