New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Report uri icon

Overview

MeSH Major

  • Apoptosis
  • Carrier Proteins
  • Phosphatidylinositol 3-Kinases
  • Protein-Serine-Threonine Kinases

abstract

  • The most recently discovered PTEN tumor suppressor gene has been found to be defective in a large number of human cancers. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors. PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides.

publication date

  • April 13, 1999

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.96.8.4240

Additional Document Info

start page

  • 4240

end page

  • 5

volume

  • 96

number

  • 8