Regression of atherosclerosis role of nitric oxide and apoptosis Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Arteriosclerosis
  • Nitric Oxide

abstract

  • These results indicate that supplemental L-arginine induces apoptosis of macrophages in intimal lesions by its metabolism to NO, which acts through a cGMP-independent pathway. These studies are consistent with our previous observation that supplementation of dietary arginine induces regression of atheroma in this animal model. These studies provide a rationale for further investigation of the therapeutic potential of manipulating the NO synthase pathway in atherosclerosis.

publication date

  • March 9, 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10069793

Additional Document Info

start page

  • 1236

end page

  • 41

volume

  • 99

number

  • 9