Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: Effect on survival
Cell Cycle Proteins
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p16
Soft Tissue Neoplasms
Tumor Suppressor Proteins
Coincident homozygous deletion of the INK4A and INK4B genes occurs frequently in adult soft tissue sarcomas. Loss of p16 and pl9ARF function in primary tumors, although not equivalent to alterations in p53 and pRB function, appears to be associated with cancers that have an aggressive biologic behavior.