Requirement for B cell linker protein (BLNK) in B cell development Academic Article Article uri icon

Overview

MeSH Major

  • Cell Cycle Proteins
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins
  • Protein-Serine-Threonine Kinases
  • Recombination, Genetic
  • Tumor Suppressor Proteins

abstract

  • Linker proteins function as molecular scaffolds to localize enzymes with substrates. In B cells, B cell linker protein (BLNK) links the B cell receptor (BCR)-activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of BLNK, mice deficient in BLNK were generated. B cell development in BLNK-/- mice was blocked at the transition from B220+CD43+ progenitor B to B220+CD43- precursor B cells. Only a small percentage of immunoglobulin M++ (IgM++), but not mature IgMloIgDhi, B cells were detected in the periphery. Hence, BLNK is an essential component of BCR signaling pathways and is required to promote B cell development.

publication date

  • December 3, 1999

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1126/science.286.5446.1949

PubMed ID

  • 10583957

Additional Document Info

start page

  • 1949

end page

  • 54

volume

  • 286

number

  • 5446