Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization. Review uri icon

Overview

MeSH

  • Animals
  • Humans
  • Prognosis
  • Sensitivity and Specificity

MeSH Major

  • Coronary Disease
  • Genetic Therapy
  • Myocardial Revascularization
  • Neovascularization, Pathologic

abstract

  • Angiogenesis, the de novo formation of new vasculature, is a critical response to ischemia that provides neovascularization of ischemic tissues. In therapeutic angiogenesis, an angiogen--a mediator that induces angiogenesis--is delivered to targeted tissues, augmenting the native angiogenic process and enhancing reperfusion of ischemic tissues. Gene transfer is a novel means of providing therapeutic angiogenesis: the cDNA coding for specific angiogens, rather than the proteins themselves, is administered to the tissues in which angiogenesis is desired. This review is focused on therapeutic angiogenesis based on gene transfer strategies for the provision of myocardial revascularization.

publication date

  • November 1999

has subject area

  • Animals
  • Coronary Disease
  • Genetic Therapy
  • Humans
  • Myocardial Revascularization
  • Neovascularization, Pathologic
  • Prognosis
  • Sensitivity and Specificity

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 10579070

Additional Document Info

start page

  • 515

end page

  • 522

volume

  • 14

number

  • 6