Haem oxygenase-1 prevents cell death by regulating cellular iron Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Heme Oxygenase (Decyclizing)
  • Iron
  • Skin

abstract

  • Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death: iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.

publication date

  • July 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10559901

Additional Document Info

start page

  • 152

end page

  • 7

volume

  • 1

number

  • 3