Ikaros sets thresholds for T cell activation and regulates chromosome propagation Academic Article uri icon

Overview

MeSH Major

  • Cell Cycle
  • Chromosomes
  • DNA-Binding Proteins
  • Lymphocyte Activation
  • T-Lymphocytes
  • Transcription Factors

abstract

  • T cell activation involves the sustained accumulation of T cell receptor (TCR) and IL-2 receptor (IL-2R) mediated signaling events that promote cell cycle entry and progression. The Ikaros family of nuclear factors regulate this process by providing thresholds overcome by receptor signaling. T cells with reduced levels of Ikaros activity require fewer TCR engagement events for activation, exhibit a greater proliferative response to IL-2, and are less sensitive to inhibitors of TCR and IL-2R signaling. Upon T cell activation, Ikaros proteins localize in a higher-order chromatin structure where they colocalize with components of the DNA replication machinery. Proliferating T cells with reduced Ikaros activity display chromosome abnormalities. We propose that participation of Ikaros in higher-order chromatin structures controls cell cycle transitions and restricts DNA replication.

publication date

  • January 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10204489

Additional Document Info

start page

  • 333

end page

  • 43

volume

  • 10

number

  • 3