An immunodominant epitope on DNA topoisomerase I is conformational in nature: Heterogeneity in its recognition by systemic sclerosis sera
Membrane Transport Proteins
Molecular Dynamics Simulation
An immunodominant epitope recognized by anti-topo I autoantibody is located in the region of amino acids 489-573 of the topo I protein and is largely conformational in nature. The recognition pattern of this region by anti-topo I-positive sera is heterogeneous and is influenced by ethnic background.