An immunodominant epitope on DNA topoisomerase I is conformational in nature: Heterogeneity in its recognition by systemic sclerosis sera Academic Article uri icon

Overview

MeSH Major

  • Cell Membrane
  • Membrane Transport Proteins
  • Molecular Dynamics Simulation
  • Sterols

abstract

  • An immunodominant epitope recognized by anti-topo I autoantibody is located in the region of amino acids 489-573 of the topo I protein and is largely conformational in nature. The recognition pattern of this region by anti-topo I-positive sera is heterogeneous and is influenced by ethnic background.

publication date

  • June 1999

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1529-0131(199906)42:6<1179::AID-ANR14>3.0.CO;2-E

Additional Document Info

start page

  • 1179

end page

  • 88

volume

  • 42

number

  • 6