Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Phytogenic
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Paclitaxel
  • Tubulin

abstract

  • We have identified beta-tubulin gene mutations as a strong predictor of response to the antitubulin drug paclitaxel; these mutations may represent a novel mechanism of resistance and should be examined prospectively in future trials of taxane-based therapy in NSCLC.

publication date

  • June 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10561216

Additional Document Info

start page

  • 1786

end page

  • 93

volume

  • 17

number

  • 6