Focal segmental glomerulosclerosis in a 32-year-old kidney allograft after 7 years without immunosuppression Academic Article uri icon


MeSH Major

  • Glomerulosclerosis, Focal Segmental
  • Immunosuppression
  • Kidney Transplantation


  • In kidney allografts, focal segmental glomerulosclerosis (FSGS) has been described as recurrent, de novo, or a histological variant of chronic transplant glomerulopathy. We describe a unique case of de novo FSGS in a renal transplant not accompanied by any feature of rejection in a patient who had not been immunosuppressed for several years. A 58-year-old woman received a histoidentical living-related kidney transplant for end-stage renal disease due to chronic pyelonephritis. Twenty-four years after the transplant she voluntarily discontinued all immunosuppressive medication. Seven years later she presented with nephrotic syndrome, mild renal failure, and positive serology for hepatitis C virus (HCV) antibody. The kidney transplant biopsy disclosed de novo FSGS. Features of acute or chronic rejection, including chronic transplant glomerulopathy, were not seen. The pathogenesis of this lesion is probably related to sustained and prolonged glomerular hyperfiltration; alternatively, HCV infection may have triggered or accelerated the appearance of FSGS.

publication date

  • July 14, 1999



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1159/000045412

PubMed ID

  • 10396000

Additional Document Info

start page

  • 270

end page

  • 3


  • 82


  • 3