Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

abstract

  • Outcome for infants on CCG-107 and CCG- 1883 improved, compared with historical controls. Marrow relapse remains the primary mode of failure. Isolated CNS relapse rates are low, indicating that intrathecal chemotherapy combined with very-high-dose systemic therapy provides adequate protection of the CNS. The overall unsatisfactory outcome observed for the infant ALL population warrants the future use of novel alternative therapies.

publication date

  • February 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10080584

Additional Document Info

start page

  • 445

end page

  • 55

volume

  • 17

number

  • 2