Efficacy of SSRIs and newer antidepressants in severe depression: Comparison with TCAs Review uri icon

Overview

MeSH Major

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Depressive Disorder
  • Serotonin Uptake Inhibitors

abstract

  • SSRIs and TCAs are comparably effective for the treatment of severe or melancholic depression. SSRIs and other newer agents appear to be better tolerated than TCAs, specifically lacking adverse anticholinergic and cardiovascular effects that may limit the use of TCAs. Emerging data with venlafaxine and mirtazapine in severely depressed patients with or without melancholia support the efficacy of these treatments. Nefazodone and bupropion were found to be effective in hospitalized depressed patients. Electroconvulsive therapy (ECT) or combined antidepressant therapy may be useful in some patients with severe depression. Patients with severe psychotic depression may respond better to an antipsychotic-antidepressant combination.

publication date

  • January 1999

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.4088/JCP.v60n0511

PubMed ID

  • 10362442

Additional Document Info

start page

  • 326

end page

  • 35

volume

  • 60

number

  • 5