Gemcitabine and paclitaxel: Pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Carcinoma, Non-Small-Cell Lung
  • Deoxycytidine
  • Lung Neoplasms
  • Paclitaxel

abstract

  • Gemcitabine and paclitaxel pharmacokinetics were related to the percentage decrease in platelets. Paclitaxel did not affect the pharmacokinetics of gemcitabine, nor did gemcitabine affect the pharmacokinetics of paclitaxel, but paclitaxel increased dFdCTP accumulation. This might enhance the antitumor activity of gemcitabine.

publication date

  • July 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10561275

Additional Document Info

start page

  • 2190

end page

  • 7

volume

  • 17

number

  • 7